Jun 19 – 22, 2024
Squamish, BC, Canada
Canada/Pacific timezone
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Clockor2: Inferring global and local strict molecular clocks using root-to-tip regression

Not scheduled
20m
Squamish, BC, Canada

Squamish, BC, Canada

Poster Software, tools & methods

Speaker

Wytamma Wirth (The Peter Doherty Institute for Infection and Immunity)

Description

Molecular sequence data from rapidly evolving organisms are often sampled at different points in time. Sampling times can then be used for molecular clock calibration. The root-to-tip (RTT) regression is an essential tool to assess the degree to which the data behave in a clock-like fashion. We introduce Clockor2, a client-side web application for conducting RTT regression (clockor2.github.io). Clockor2 uniquely allows users to quickly fit local and global molecular clocks, thus handling the increasing complexity of genomic datasets that sample beyond the assumption homogeneous host populations. Although clockor2 is written as a web application, all data processing happens on the client-side, meaning that data never leaves the user’s computer. This talk will detail the implementation of Clockor2 and it's utility for studying infectious disease dynamics.

Primary authors

Andrew Rambaut (Institute of Ecology and Evolution, University of Edinburgh, Edinburgh, UK) Leo Featherstone (Peter Doherty Institute for Infection and Immunity, University of Melbourne, Australia) Sebastian Duchene (Peter Doherty Institute for Infection and Immunity, University of Melbourne, Australia) Wytamma Wirth (The Peter Doherty Institute for Infection and Immunity)

Presentation materials

There are no materials yet.